Predisposition to ALL and Solid Tumors Rather Than Bone Marrow Failure in <i>FANCM</i> -Associated Fanconi Anemia
Biallelic <i>FANCM</i> variants define a distinct FA subtype lacking early BMF, leading to missed diagnoses and severe toxicity upon malignancy. Recognizing this presentation is crucial for timely FA detection and for implementing adapted therapeutic and follow-up strategies.
Authors
- F. Pegoraro
- Catherine Paillard (ORCID: https://orcid.org/0000-0003-1662-5446)
- Jean‐Hugues Dalle (ORCID: https://orcid.org/0000-0002-8406-0793)
- Emmanuelle Clappier (ORCID: https://orcid.org/0000-0001-7098-092X)
- R. Kim
- Christophe Lachaud (ORCID: https://orcid.org/0000-0003-2762-1619)
- Thierry Leblanc (ORCID: https://orcid.org/0000-0003-2463-9346)
- N. Auger
- L. Larcher
- Nadia Vasquez
- Mélanie Da Costa
- Lucie Hernandez
- M. De Tersant
- Mélanie Pagès
- Mony Fahd
- Aurélie Caye-Eude
- Flore Sicre de Fontbrune
- Dominique Stoppa-Lyonnet
- Benoit Brethon
- Jean Soulier
- Elisabeth Luporsi
- Régis Peffault de Latour
- Marie Passet
- Marie Sébert
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Institut Gustave Roussy (FR)
- Hôpital Femme Mère Enfant (FR)
- Acute Leukemia French Association (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre Hospitalier Régional de Metz-Thionville (FR)
- Hôpital Robert-Debré (FR)
- Institut Cochin (FR)
- Hôpital Saint-Louis (FR)
- Hôpitaux Universitaires de Strasbourg (FR)
- Institut Paoli-Calmettes (FR)
- Hôpital d'Hautepierre (FR)
- University of Florence (IT)
- Institut Curie (FR)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1200/po-25-01089
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00