Biomarker tests of progression from tuberculosis infection to disease: a systematic review
No biomarker-based test to predict TB progression is currently ready for clinical implementation. Standardised methodologies, larger validation studies and improved reporting transparency are necessary to advance TB diagnostics and improve early detection efforts. Future research should prioritise refining tests for TB progression by improving their predictive accuracy, identifying appropriate target populations and evaluating their cost-effectiveness and feasibility for integration into TB prevention programmes, particularly in high-burden settings.
Authors
- Emily MacLean (ORCID: https://orcid.org/0000-0001-9272-0985)
- Kylie Tingley (ORCID: https://orcid.org/0000-0003-4165-7378)
- Giorgia Sulis (ORCID: https://orcid.org/0000-0001-6641-0094)
- Nawal Maredia
- Rajalakshmi Ravikumar
- Gonzalo Alvarez
- Alberto Matteelli
- Angela Li
- Becky Skidmore
Institutions
- The University of Sydney (AU)
- University of Ottawa (CA)
- Ottawa Hospital (CA)
- Taronga Conservation Society Australia (AU)
- Oldham Council (GB)
- National Health and Medical Research Council (AU)
- Ottawa Hospital Research Institute (CA)
- University of Brescia (IT)
Publication Details
- Journal
- European Respiratory Review
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1183/16000617.0151-2025
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00