Best evidence for managing cutaneous immune-related adverse events in cancer: A summary from chinese and english literature

Objective: This study aims to summarize the best evidence for cutaneous immunerelated adverse events (cirAEs) nursing in cancer patients, which provides theoretical support for standardizing the preventive, assessment, grading, nursing interventions, and follow-up of various cirAEs.Methods: Guided by the 6S evidence hierarchy, a comprehensive search was conducted in Chinese and English databases including UpToDate, BMJ Best Practice, Cochrane Library, PubMed, Embase, CINAHL, SinoMed, CNKI, Wanfang, and VIP databases, as well as 19 guideline or academic websites, retrieving evidence from the database's inception to November 5 th , 2025.Two reviewers independently screened and appraised eligible publications, including guidelines, evidence summaries, clinical decisions, expert consensuses, and systematic reviews.Results: A total of 24 Chinese and English articles were included, comprising 7 guidelines, 3 systematic reviews, 9 expert consensuses, 2 clinical decisions, and 3 evidence summaries.We identified 25 best-evidence recommendations across five key dimensions: prevention, assessment, grading, nursing interventions, health education, J o u r n a l P r e -p r o o f and follow-up.Following expert evaluation based on the FAME framework, 17 recommendations were graded as strong and 8 as weak.Conclusions: This study consolidates evidence-based recommendations from Chinese and English literature for cirAEs nursing management.Clinical implementation should integrate patient preferences, contextual factors, and potential barriers to evidence application.Ongoing assessment of emerging research is warranted.