Intermediate Dose Heparin Thromboprophylaxis among Critically Ill Patients with COVID-19: A Randomised Clinical Trial
Intermediate-dose heparin did not improve organ support-free days or survival compared with standard thromboprophylaxis in critically ill patients with COVID-19. (ClinicalTrials.gov number:CT02735707).
Authors
- India Loar (ORCID: https://orcid.org/0000-0002-4758-3050)
- Shigeki Fujitani (ORCID: https://orcid.org/0000-0001-6327-682X)
- Sarah Englert
- Svenja Peters
- Stéphan Ehrmann (ORCID: https://orcid.org/0000-0001-6221-4467)
- Yoshiaki Yamagishi (ORCID: https://orcid.org/0000-0002-9163-787X)
- Barnaby Edward Young (ORCID: https://orcid.org/0000-0003-1010-2230)
- David A Harrison (ORCID: https://orcid.org/0000-0002-9002-9098)
- Hannah Tolley (ORCID: https://orcid.org/0000-0002-9887-7112)
- Ian Seppelt (ORCID: https://orcid.org/0000-0003-3682-5007)
- Carly Au (ORCID: https://orcid.org/0000-0003-1385-9239)
- Victoria Manax
- Hiroyuki Kunishima (ORCID: https://orcid.org/0000-0003-1992-5866)
- Jeffrey Presneill (ORCID: https://orcid.org/0000-0001-7177-7667)
- Susan C. Morpeth (ORCID: https://orcid.org/0000-0002-6131-8536)
- Sewa Duu Wen
- Peter Krüger (ORCID: https://orcid.org/0000-0002-3216-2958)
- Venika Manoharan
- Julian Bion (ORCID: https://orcid.org/0000-0003-0344-5403)
- Arjen Dondrop
- Patrick R. Lawler (ORCID: https://orcid.org/0000-0001-5155-5071)
- Kenichi Nakazono
- Andrew Forbes (ORCID: https://orcid.org/0000-0003-4269-914X)
- David Gattas (ORCID: https://orcid.org/0000-0002-9282-7093)
- Michael Laffan (ORCID: https://orcid.org/0000-0002-8268-3268)
- Ewan C. Goligher (ORCID: https://orcid.org/0000-0002-0990-6701)
- Sylvain Lother (ORCID: https://orcid.org/0000-0003-1927-2682)
- Brian Alexander (ORCID: https://orcid.org/0000-0002-0581-2994)
- Janis Best-Lane (ORCID: https://orcid.org/0000-0003-2528-898X)
- Bastian Lubis (ORCID: https://orcid.org/0000-0002-1839-4146)
- Stéphane Héritier (ORCID: https://orcid.org/0000-0002-3640-079X)
- Monvasi Pachinburavan
- Meredith Buxton (ORCID: https://orcid.org/0000-0003-0104-0429)
- Florian Mayr (ORCID: https://orcid.org/0000-0002-2298-9011)
- Elizabeth Lorenzi (ORCID: https://orcid.org/0000-0002-7259-2696)
- Anthony C. Gordon (ORCID: https://orcid.org/0000-0002-0419-547X)
- Claire Reynolds (ORCID: https://orcid.org/0000-0003-3452-0832)
- Paul R. Mouncey (ORCID: https://orcid.org/0000-0002-8510-8517)
- Kazuhiro Kamata (ORCID: https://orcid.org/0000-0002-3479-2961)
- Shailesh Bihari (ORCID: https://orcid.org/0000-0001-7553-8620)
- Lyle Murray (ORCID: https://orcid.org/0000-0002-3577-284X)
- Sumayyah Rashan (ORCID: https://orcid.org/0000-0001-8657-9639)
- Ismail Kalla (ORCID: https://orcid.org/0000-0001-9131-7123)
- Alisa M. Higgins (ORCID: https://orcid.org/0000-0001-8295-7559)
- Shay McGuinness (ORCID: https://orcid.org/0000-0003-0620-4787)
- Vanessa Singh
- Mathias W. Pletz (ORCID: https://orcid.org/0000-0001-8157-2753)
- Manoj Saxena (ORCID: https://orcid.org/0000-0002-0385-6731)
- Kazuaki Jindai (ORCID: https://orcid.org/0000-0003-4679-3862)
- Michelle A. Detry (ORCID: https://orcid.org/0000-0002-2794-1439)
- Leanne Hays (ORCID: https://orcid.org/0000-0002-6936-1459)
- Bryan J. McVerry (ORCID: https://orcid.org/0000-0002-1175-4874)
- Frank L. van de Veerdonk (ORCID: https://orcid.org/0000-0002-1121-4894)
- Julian de la Torre Cisneros
- Thomas Hills (ORCID: https://orcid.org/0000-0003-0322-5822)
- Maurizio Cecconi
- Christina Saunders (ORCID: https://orcid.org/0000-0003-4325-9568)
- Matthew E. Cove (ORCID: https://orcid.org/0000-0003-3805-4680)
- Anna McGlothlin (ORCID: https://orcid.org/0000-0002-9079-6166)
- Kim Basile
- Tsin Wen Yeo (ORCID: https://orcid.org/0000-0002-4060-7902)
- Nattachai Srisawat (ORCID: https://orcid.org/0000-0002-8544-8132)
- Hitoshi Honda
- Hiroki Saito (ORCID: https://orcid.org/0000-0002-7355-3234)
- Tracey Roberts
- Lindsay R. Berry (ORCID: https://orcid.org/0009-0003-4782-2570)
- Anne Turner (ORCID: https://orcid.org/0000-0002-4092-1424)
- Kathryn Rowan
- Jason Phua
- Chizuru Yamashita
- Nao Ichihara
- Roger E.G. Schutgens
- Srinivas Murthy
- Yohei Doi
- Manu Shankar-Hari
- Eveline D. Verheijen
- Diptesh Aryal
- Christine M. Leeper
- Christopher W. Seymour
- Lise J. Estcourt
- Saskia Middeldorp
- Matthew D. Neal
- Lane Carrandi
- Lusi Felipe Reyes
- Manu Shankar Hari
- Tom van der Poll
- Rachael L. Parke
- Mark Fitzgerald
- Rob A. Fowler
- Luis Felipe Reyes
- Alexis F. Turgeon
- Leanne M.C. Hays
- Derek Angus (
- Devachandran Jayakumar
- Sebastian Weis
- Ayumi Shintani
- Christopher M. Horvat
- Aidan Burrell
- Roger J. Lewis
- Jenny Low
- Abigail Beane
- Djillali Annane
- Abdul Jabber Bin Ismail
- Jason Connor
- Charlotte A. Bradbury
- John Marshall (
- Jane C. Parker
- Madiha Hashmi
- Zoe K. McQuilten
- Rashan Haniffa
- Ryan Zarychanski
- Brian Cuthbertson
- Frank Brunkhorst
- Yaseen M. Arabi
- Marlene Santos
- David T. Huang
- Simon Gates
- Dean A. Fergusson
- Simon J. Stanworth
- Marc Bonten
- John Warren Reynolds
- Steve Webb (
- Colin J. McArthur
- Timothy Girard
- Ryan Zarychanski ; Yaseen Arabi
- Mohd Shahnaz Bin Hasan
- Paul Tambyah
- Bec Ward-Smith
- Anand Kumar
- Anne Turner
- Faheem Ahmed Khan
- Hideaki Kato
- Derek C. Angus
- Marc Carrier
- Cameron Green
- Stephanie Keattch
- Lennie P.G. Derde
- Ali Smith
- Allen C. Cheng
- John C. Marshall
- Alistair D. Nichol
- Ryanna Koh
- Francois Lamontagne
- Scott M. Berry
- Daniel F. McAuley
- Beverley J. Hunt
- Steve A. Webb
- Lewis Campbell
- Sandra Peake
- Paul Young
- Tony Trapani
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1016/j.jtha.2026.03.006
- Primary Topic
- Heparin-Induced Thrombocytopenia and Thrombosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00