Temocillin: a therapeutic alternative in bone and joint infections due to third generation cephalosporin-resistant Enterobacterales?
This study demonstrated the high in vitro efficacy of temocillin against 3GC-R Enterobacterales from BJIs, regardless of the underlying resistance mechanism. However, dosage adjustments based on the strain's MIC and the patient's renal function are crucial for optimal efficacy.
Authors
- Mathieu Maillard (ORCID: https://orcid.org/0000-0001-7290-2925)
- Sandrine Boisset (ORCID: https://orcid.org/0000-0001-8717-8749)
- Louise Piquart
- C. Dupieux
- Anne Tristan
- Anne-Gaëlle Ranc
- Frédéric Laurent
- Anne Carricajo
- Sylvain Goutelle
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Hôpital de la Croix-Rousse (FR)
- Hospices Civils de Lyon (FR)
- Laboratoire de Biométrie et Biologie Evolutive (FR)
- Centre Hospitalier Universitaire de Saint-Étienne (FR)
- Centre International de Recherche en Infectiologie (FR)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1093/jac/dkag105
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00