Systemic metabolic signatures of apical periodontitis detected by Fourier-transform infrared spectroscopy in a rat model
Serum spectra demonstrated better discriminant performance than urine spectra in the PCA-LDA model. These findings support the systemic impact of endodontic infection and highlight the potential of FTIR as a non-invasive tool for investigating the biochemical interface between apical periodontitis and systemic health.
Authors
- Luis Felipe das Chagas e Silva de Carvalho (ORCID: https://orcid.org/0000-0003-1063-4624)
- Rayana Duarte Khoury (ORCID: https://orcid.org/0000-0001-6403-8348)
- Giovana dos Santos Toledo
- Julia Nani Bittencourt Gouvêa
- Marcia Carneiro Valera
- Paula Cristina Marcelino Marinho
- Maryane Pereira Rezende
Institutions
- Universidade de Taubaté (BR)
- Department of Aerospace Science and Technology (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1016/j.pdpdt.2026.105454
- Primary Topic
- Spectroscopy Techniques in Biomedical and Chemical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00