Chapter 2: Fundamentals of chiral spectroscopy

This chapter provides an overview of the origins of chiral-sensitivity, starting from optical spectroscopy, and then presents different approaches for studying chirality through NMR. The corresponding chiral observables and their underlying symmetries are discussed in the context of interactions between light and chiral molecules, magnetic dichroism, and NMR spectroscopy. The foundations of well-established indirect methods, such as the application of chiral agents and measurements of residual dipolar coupling, are presented, along with direct methods that have not yet been experimentally observed.