Novel integrase mutations linked to genotypic DTG resistance in African non-B HIV-1 strains: the DTG RESIST study

We identified several amino acid substitutions outside the established DRMs that are strongly associated with predicted dolutegravir resistance. Dolutegravir resistance evolution is complex and likely involves mutations not currently classified as DRMs.

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Publication Details

Journal
Journal of Antimicrobial Chemotherapy
Published
2026-03-04
DOI
https://doi.org/10.1093/jac/dkag088
Primary Topic
HIV/AIDS drug development and treatment
Type
article
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article

Novel integrase mutations linked to genotypic DTG resistance in African non-B HIV-1 strains: the DTG RESIST study

Journal of Antimicrobial Chemotherapy
HIV/AIDS drug development and treatment
article

Novel integrase mutations linked to genotypic DTG resistance in African non-B HIV-1 strains: the DTG RESIST study

article en

Abstract

We identified several amino acid substitutions outside the established DRMs that are strongly associated with predicted dolutegravir resistance. Dolutegravir resistance evolution is complex and likely involves mutations not currently classified as DRMs.

Journal of Antimicrobial ChemotherapyVol. 81(4)
University of Bern (CH), Centre for Infectious Disease Research in Zambia (ZM), AIDS Healthcare Foundation (US), Mbarara University of Science and Technology (UG), University of Cape Town (ZA), University of Zurich (CH), Centre for the AIDS Programme of Research in South Africa (ZA), Masaka Hospital (UG), Education and Research Network (IN), Nazi Boni University (BF), University of Alabama at Birmingham (US), University of Bristol (GB), Lighthouse Trust (MW), Public Health Department (IN), Biomedical Research and Training Institute (ZW), University Hospital of Zurich (CH), Centre Hospitalier et Universitaire de Brazzaville (CG), Infectious Diseases Institute (UG), CHU Dijon Bourgogne (FR), Goodlife (Netherlands) (NL), Société de Développement des Forêts (CI), Institute of Social and Preventive Medicine (CH), Programme PAC-CI (CI), West African Health Organisation (BF), Indiana University School of Medicine, Indiana University – Purdue University Indianapolis (US), Makerere University (UG), University of KwaZulu-Natal (ZA)
Good health and well-being
Openalex Percentile: Top 11%
HIV/AIDS drug development and treatment
DOIOpen Access PDFOpenAlex
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Novel integrase mutations linked to genotypic DTG resistance in African non-B HIV-1 strains: the DTG RESIST study · Journal of Antimicrobial Chemotherapy (2026) | TGRS Research Map | TGRS