Host-viral interaction of HBV infection revealed by single-cell transcriptome jointly profiling the viral replication state
In summary, our B-BEST platform provides resources for delineating the heterogeneous landscape of HBV infection, identifying host determinants and microenvironmental factors that govern viral replication and persistence, and highlighting hepatocyte proliferation as a potential clearance mechanism for antiviral therapy.
Authors
- Jinhang He (ORCID: https://orcid.org/0009-0003-5534-7079)
- Zhongliang Shen (ORCID: https://orcid.org/0000-0001-8566-9149)
- Qiran Zhang (ORCID: https://orcid.org/0000-0002-0158-3821)
- QuanBao Zhang
- Jingshen Wang (ORCID: https://orcid.org/0000-0002-1432-3834)
- Zaoxu Xu
- Caixia Zheng (ORCID: https://orcid.org/0000-0003-4028-6149)
- Ning Jiang (ORCID: https://orcid.org/0000-0002-9797-763X)
- Xiaomu Hu (ORCID: https://orcid.org/0000-0003-3941-4297)
- Renjie Liao
- Miaoqu Zhang
- Yu Zhang (ORCID: https://orcid.org/0000-0003-3474-422X)
- Yongping Liu (ORCID: https://orcid.org/0000-0002-6466-483X)
- Rongshan Fan
- Jianming Zheng (ORCID: https://orcid.org/0009-0009-3018-5740)
- Zunguo Du
- Chao Qiu
- Jiming Zhang
- Guojun Li
- Zhengxin Wang
- Yanfang Huang
- Zhang Xia
- Shengran Jiang
- Hongyuan Xue
- Yuxian Huang
- Wenqi Zhu
- Luyang Zhao
- Wenhong Zhang
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Southern University of Science and Technology (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Singleron Biotechnologies (china) (CN)
- Hangzhou Xixi hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Shanghai Institute of Hematology (CN)
- Salus (United States) (US)
- Huashan Hospital (CN)
- Shenzhen Pingle Orthopedic Hospital (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1097/hep.0000000000001750
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00