Combined prognostic impact of complex karyotype and <i>KIT</i> mutations refines risk stratification in t(8;21) acute myeloid leukemia

CK and KIT mutations jointly identify a high-risk subgroup within t(8;21) AML. This baseline genetic stratification provides a foundation for risk-adapted therapy, with MRD assessment at CR offering complementary prognostic information.

Institutions

Zhejiang Lab (CN)
First Affiliated Hospital Zhejiang University (CN)
Zhejiang University (CN)

Publication Details

Journal: Cancer
Published: 2026-03-24
DOI: https://doi.org/10.1002/cncr.70370
Primary Topic: Acute Myeloid Leukemia Research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Combined prognostic impact of complex karyotype and KIT mutations refines risk stratification in t(8;21) acute myeloid leukemia

Mar 24, 2026

Cancer

Acute Myeloid Leukemia Research

article

Combined prognostic impact of complex karyotype and KIT mutations refines risk stratification in t(8;21) acute myeloid leukemia

March 24, 2026article en

Abstract

CancerVol. 132(7)

Zhejiang Lab (CN), First Affiliated Hospital Zhejiang University (CN), Zhejiang University (CN)

Openalex Percentile: Top 10%

Acute Myeloid Leukemia Research

DOI Source OpenAlex

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Combined prognostic impact of complex karyotype and <i>KIT</i> mutations refines risk stratification in t(8;21) acute myeloid leukemia · Cancer (2026) | TGRS Research Map | TGRS