Estimating the sensitivity of non-treponemal and treponemal antibody tests in primary syphilis
Among patients with primary syphilis, sensitivity of TRUST was 55% (6/11) compared to darkfield microscopy (DFM) and 60% (9/15) compared to Treponema pallidum PCR. Sensitivity of RPR was 78% (38/49) and 93% (43/46), respectively. TPPA had a sensitivity of 95% (41/43) compared to DFM and 96% (43/45) compared to PCR.
Authors
- A. C. Sena
- J Chen
- Stephanie Sweitzer (ORCID: https://orcid.org/0000-0002-4567-5920)
- Justin D. Radolf (ORCID: https://orcid.org/0000-0002-9341-6712)
- Liu Yang (ORCID: https://orcid.org/0000-0002-4179-8587)
- Ilse Hoffman (ORCID: https://orcid.org/0000-0002-2541-4117)
- Mitch Matoga (ORCID: https://orcid.org/0000-0002-6542-8193)
- Eduardo López-Medina
- Jonny A. García-Luna
- Juan C. Salazar
- Jonathan B. Parr
- Bin Yang
Institutions
- University of North Carolina at Chapel Hill (US)
- Centro Internacional de Entrenamiento e Investigaciones Medicas (CO)
- Connecticut Children's Medical Center (US)
- Hartford Financial Services (United States)
- Southern Medical University (CN)
- UConn Health (US)
- Icesi University (CO)
- Universidad del Valle (CO)
Publication Details
- Journal
- Sexually Transmitted Diseases
- Published
- 2026-03-24
- DOI
- https://doi.org/10.1097/olq.0000000000002297
- Primary Topic
- Syphilis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00