Novel protein biomarkers for risk stratification and personalized medicine

Urinary clusterin and uEGF are mechanism-informed pharmacodynamic biomarkers reflecting distinct intrarenal pathways engaged by ERA and SGLT2i therapy, respectively. These biomarkers complement albuminuria by capturing tubular injury and repair, providing a more comprehensive biological assessment of treatment effects and heterogeneity in CKD.

Publication Details

Journal
Nephrology Dialysis Transplantation
Published
2026-03-20
DOI
https://doi.org/10.1093/ndt/gfag068
Primary Topic
Clusterin in disease pathology
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Novel protein biomarkers for risk stratification and personalized medicine

Nephrology Dialysis Transplantation
Clusterin in disease pathology
article

Novel protein biomarkers for risk stratification and personalized medicine

article en

Abstract

Urinary clusterin and uEGF are mechanism-informed pharmacodynamic biomarkers reflecting distinct intrarenal pathways engaged by ERA and SGLT2i therapy, respectively. These biomarkers complement albuminuria by capturing tubular injury and repair, providing a more comprehensive biological assessment of treatment effects and heterogeneity in CKD.

Nephrology Dialysis Transplantation
Good health and well-being
Openalex Percentile: Top 10%
Clusterin in disease pathology
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Novel protein biomarkers for risk stratification and personalized medicine · Nephrology Dialysis Transplantation (2026) | TGRS Research Map | TGRS