Novel protein biomarkers for risk stratification and personalized medicine
Urinary clusterin and uEGF are mechanism-informed pharmacodynamic biomarkers reflecting distinct intrarenal pathways engaged by ERA and SGLT2i therapy, respectively. These biomarkers complement albuminuria by capturing tubular injury and repair, providing a more comprehensive biological assessment of treatment effects and heterogeneity in CKD.
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2026-03-20
- DOI
- https://doi.org/10.1093/ndt/gfag068
- Primary Topic
- Clusterin in disease pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00