Revealing the therapeutic potential of Laminaria japonica polysaccharides against cataract: evidence from transcriptomics, network pharmacology, and in vivo experiments

These findings suggest that LPs may attenuate UVB-induced cataract by targeting XDH, ANPEP, and SNCA. In vivo evidence further indicates that this intervention enhances antioxidant defenses, as reflected by increased SOD activity and upregulation of SMP30 and FoxO4, while suppressing apoptosis, thereby contributing to protection against lens damage.