An intrinsically disordered tug of war that fine-tunes acetylation

Acetylation of histones and transcriptional regulators modulates gene expression, but how acetyltransferases define target specificity remains puzzling. In Cell Reports, Gelder et al.<sup>1</sup> have shown how intrinsically disordered regions of CBP temper each other to shape acetyltransferase activity.

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Publication Details

Journal
Cell Reports
Published
2026-03-24
DOI
https://doi.org/10.1016/j.celrep.2026.117206
Primary Topic
Protein Structure and Dynamics
Type
article
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article

An intrinsically disordered tug of war that fine-tunes acetylation

Cell Reports
Protein Structure and Dynamics
article

An intrinsically disordered tug of war that fine-tunes acetylation

article en

Abstract

Acetylation of histones and transcriptional regulators modulates gene expression, but how acetyltransferases define target specificity remains puzzling. In Cell Reports, Gelder et al.<sup>1</sup> have shown how intrinsically disordered regions of CBP temper each other to shape acetyltransferase activity.

Cell ReportsVol. 45(4)
Carnegie Mellon University (US)
Zero hunger
Openalex Percentile: Top 10%
Protein Structure and Dynamics
DOIOpen Access PDFOpenAlex
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An intrinsically disordered tug of war that fine-tunes acetylation · Cell Reports (2026) | TGRS Research Map | TGRS