Metabolic Markers in Bipolar Disorder with Childhood Trauma Exposure: A Systematic Review

Background:Bipolar disorder (BD) is associated with increased cardiometabolic risk, contributing to elevated morbidity and premature mortality.Childhood trauma (CT) is a common environmental risk factor in BD and may exacerbate metabolic dysfunction, but no prior systematic synthesis has focused on their intersection. Objective:To systematically review and synthesize evidence on the association between childhood trauma exposure and metabolic biomarkers in adults with bipolar disorder. Methods:This review adhered to PRISMA 2020 guidelines and was registered in PROSPERO (ID 1045565).A comprehensive search of PubMed/MEDLINE, Web of Science, Scopus, and Embase (from inception to September 2025) was conducted.Eligible studies were peer-reviewed observational studies assessing associations between CT and metabolic markers (e.g., BMI, lipids, HbA1c, hs-CRP) in adult BD populations.Data extraction and NIH quality assessments were performed independently by multiple reviewers.