<scp>ALDOA</scp> Promotes Glycolysis and <scp>NLRP3</scp> / <scp>GSDMD</scp> Pyroptosis to Accelerate <scp>ALS</scp> Progression
We show that ALDOA-mediated glycolytic dysregulation activates the NLRP3/GSDMD inflammasome, leading to pyroptosis in motor neurons. Pharmacological inhibition of ALDOA alleviates glycolytic dysregulation and extends survival, identifying ALDOA as a potential therapeutic target.
Institutions
- Central South University (CN)
- Xinjiang Medical University (CN)
- Sun Yat-sen University (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
- Xiangya Hospital Central South University (CN)
- Second Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2026-03-24
- DOI
- https://doi.org/10.1002/acn3.70372
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00