A high-precision image-guided platform for studying spinal cord toxicity under ultra-high dose rate electron irradiation
We developed the first comprehensive, image-guided preclinical platform for accurate UHDR and CONV irradiation to investigate FLASH-mitigated spinal cord toxicity in rats. This work thus establishes a robust foundation for systematic evaluation of the FLASH effect in late-responding organs and for assessing relevant clinical applicability of FLASH-RT.
Institutions
- University of Wisconsin–Madison (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Southwestern Medical Center (US)
- University of Baltimore (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Physics in Medicine and Biology
- Published
- 2026-03-24
- DOI
- https://doi.org/10.1088/1361-6560/ae56cb
- Primary Topic
- Advanced Radiotherapy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00