Decellularized Dental Pulp Matrix Hydrogel Promotes Functional Endodontic Regeneration In Situ

This study demonstrated the significance of pDDPM-G in functional endodontic regeneration using an orthotopic canine model. It was found that the use of pDDPM-G was not only beneficial for root development but also facilitated pulp-like tissue morphogenesis, dentinogenesis, angiogenesis and neurogenesis, thereby reconstructing hierarchically distributed functional pulp-dentine complexes.