Legumain‐Mediated Activation of <scp>PAR</scp> 2 Contributes to Mechanical Hypersensitivity in a Rat Model of Tongue Cancer

These findings suggest that legumain released from SCC cells activates PAR2 on primary afferent terminals, leading to the mechanical sensitization of cancerous tongues. This study provides novel insights into the peripheral mechanisms of oral SCC pain.

Institutions

Publication Details

Journal
Oral Diseases
Published
2026-03-24
DOI
https://doi.org/10.1111/odi.70290
Primary Topic
Protease and Inhibitor Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Legumain‐Mediated Activation of PAR 2 Contributes to Mechanical Hypersensitivity in a Rat Model of Tongue Cancer

Oral Diseases
Protease and Inhibitor Mechanisms
article

Legumain‐Mediated Activation of PAR 2 Contributes to Mechanical Hypersensitivity in a Rat Model of Tongue Cancer

article en

Abstract

These findings suggest that legumain released from SCC cells activates PAR2 on primary afferent terminals, leading to the mechanical sensitization of cancerous tongues. This study provides novel insights into the peripheral mechanisms of oral SCC pain.

Oral Diseases
Nihon University (JP), Yokohama City University (JP)
Openalex Percentile: Top 10%
Protease and Inhibitor Mechanisms
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Legumain‐Mediated Activation of <scp>PAR</scp> 2 Contributes to Mechanical Hypersensitivity in a Rat Model of Tongue Cancer · Oral Diseases (2026) | TGRS Research Map | TGRS