Unsupervised Phenomapping of Perioperative Risk in Stable Coronary Artery Disease: Revealing Limitations of the Revised Cardiac Risk Index

Perioperative risk in stable CAD is phenotype-dependent. In this single-center cohort, RCRI performance varied by phenotype and may misclassify risk in clinically important high-risk phenotypes, particularly those characterized by occult ischemia or metabolic dysregulation. CHALSA showed more stable performance across phenotypes, but external validation is needed before broader clinical adoption.

Publication Details

Journal
European Journal of Preventive Cardiology
Published
2026-03-21
DOI
https://doi.org/10.1093/eurjpc/zwag169
Primary Topic
Cardiac, Anesthesia and Surgical Outcomes
Type
article
Field-Weighted Citation Impact
0.00
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article

Unsupervised Phenomapping of Perioperative Risk in Stable Coronary Artery Disease: Revealing Limitations of the Revised Cardiac Risk Index

European Journal of Preventive Cardiology
Cardiac, Anesthesia and Surgical Outcomes
article

Unsupervised Phenomapping of Perioperative Risk in Stable Coronary Artery Disease: Revealing Limitations of the Revised Cardiac Risk Index

article en

Abstract

Perioperative risk in stable CAD is phenotype-dependent. In this single-center cohort, RCRI performance varied by phenotype and may misclassify risk in clinically important high-risk phenotypes, particularly those characterized by occult ischemia or metabolic dysregulation. CHALSA showed more stable performance across phenotypes, but external validation is needed before broader clinical adoption.

European Journal of Preventive Cardiology
Reduced inequalities, Peace, Justice and strong institutions
Openalex Percentile: Top 20%
Cardiac, Anesthesia and Surgical Outcomes
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Unsupervised Phenomapping of Perioperative Risk in Stable Coronary Artery Disease: Revealing Limitations of the Revised Cardiac Risk Index · European Journal of Preventive Cardiology (2026) | TGRS Research Map | TGRS