Therapeutic potential of 20-Hydroxyecdysone in pulmonary arterial hypertension: involvement of Mas receptor and PI3K–Akt pathway

20E inhibits PASMC proliferation and migration through Mas-dependent mechanisms and modulation of downstream PI3K-Akt signaling, thereby effectively preventing and rescuing PAH. It may be a promising pharmacological candidate for PAH treatment.

Institutions

Qiqihar University (CN)
Qiqihar Medical University (CN)

Publication Details

Journal: Cellular & Molecular Biology Letters
Published: 2026-03-24
DOI: https://doi.org/10.1186/s11658-026-00880-5
Primary Topic: Pulmonary Hypertension Research and Treatments
Type: article
Field-Weighted Citation Impact: 0.00

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article

Therapeutic potential of 20-Hydroxyecdysone in pulmonary arterial hypertension: involvement of Mas receptor and PI3K–Akt pathway

Mar 24, 2026

Cellular & Molecular Biology Letters

Pulmonary Hypertension Research and Treatments

article

Therapeutic potential of 20-Hydroxyecdysone in pulmonary arterial hypertension: involvement of Mas receptor and PI3K–Akt pathway

March 24, 2026article en

Abstract

Cellular & Molecular Biology Letters

Qiqihar University (CN), Qiqihar Medical University (CN)

Good health and well-being

Openalex Percentile: Top 11%

Pulmonary Hypertension Research and Treatments

DOI Open Access PDF OpenAlex

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