The molecular mechanism underlying the differential subcellular distribution of dystrophin Dp71 isoforms
Alternative splicing at exon 78, generates an NES unique to Dp71f, which dictates subcellular localization and function of this isoform. As a result, Dp71f is efficiently exported and becomes predominantly cytoplasmic, whereas Dp71d, without this NES, is exported less efficiently and remains longer in the nucleus.
Institutions
- Universidad Autónoma del Estado de México (MX)
- Instituto Nacional de Rehabilitación (MX)
- Asociación Mexicana de Psicología y Desarrollo Comunitario (MX)
- Centro de Investigación en Materiales Avanzados (MX)
- Instituto Nacional de Pediatria (MX)
- Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (MX)
- Universidad Nacional Autónoma de México (MX)
- Tecnológico de Monterrey (MX)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2026-03-24
- DOI
- https://doi.org/10.1186/s13578-026-01566-3
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00