Pathogenesis of pseudorabies virus in mouse placenta: insights into maternal–infant transmission mechanisms

Pseudorabies virus can be transmitted vertically by disrupting the barrier function of the placenta. Maternal viremia drives preferential PRV replication within the placenta. PRV preferentially colonizes decidual and labyrinthine placental regions. PRV can cause pregnancy failure via inflammation.

Publication Details

Journal
Microbiology Spectrum
Published
2026-03-24
DOI
https://doi.org/10.1128/spectrum.03648-25
Primary Topic
Herpesvirus Infections and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Pathogenesis of pseudorabies virus in mouse placenta: insights into maternal–infant transmission mechanisms

Microbiology Spectrum
Herpesvirus Infections and Treatments
article

Pathogenesis of pseudorabies virus in mouse placenta: insights into maternal–infant transmission mechanisms

article en

Abstract

Pseudorabies virus can be transmitted vertically by disrupting the barrier function of the placenta. Maternal viremia drives preferential PRV replication within the placenta. PRV preferentially colonizes decidual and labyrinthine placental regions. PRV can cause pregnancy failure via inflammation.

Microbiology Spectrum
Good health and well-being
Openalex Percentile: Top 13%
Herpesvirus Infections and Treatments
DOIOpen Access PDFOpenAlex
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