Slow-Release Oral Morphine vs Methadone for Opioid Use Disorder in the Fentanyl Era

In this comparative effectiveness study of adults with OUD in a Canadian setting, treatment discontinuation was common. Compared with methadone, SROM was associated with a slightly higher risk of treatment discontinuation and lower adherence but similar mortality risk. The findings suggest either medication may be appropriate if measures are in place to support retention.

Institutions

Publication Details

Journal
JAMA Network Open
Published
2026-03-24
DOI
https://doi.org/10.1001/jamanetworkopen.2026.2970
Primary Topic
Opioid Use Disorder Treatment
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Slow-Release Oral Morphine vs Methadone for Opioid Use Disorder in the Fentanyl Era

JAMA Network Open
Opioid Use Disorder Treatment
article

Slow-Release Oral Morphine vs Methadone for Opioid Use Disorder in the Fentanyl Era

article en

Abstract

In this comparative effectiveness study of adults with OUD in a Canadian setting, treatment discontinuation was common. Compared with methadone, SROM was associated with a slightly higher risk of treatment discontinuation and lower adherence but similar mortality risk. The findings suggest either medication may be appropriate if measures are in place to support retention.

JAMA Network OpenVol. 9(3)
Boston University (US), Boston Medical Center (US), University of British Columbia (CA), British Columbia Centre on Substance Use (CA)
Good health and well-being
Openalex Percentile: Top 13%
Opioid Use Disorder Treatment
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.