Galectin-3 Promotes Graft Injury via NLRP3 Pyroptosis in Steatotic Liver Transplantation: A Therapeutic Target for Donor Optimization
Steatotic donor livers are highly susceptible to post-transplant dysfunction; however, the underlying mechanisms remain incompletely understood. This study aimed to investigate the role of galectin-3 (LGALS3)-mediated pyroptosis in steatotic liver graft injury and explore its therapeutic potential.
Authors
- Yingquan Zhuo
- Xianwu Yang
- Ji Ae Yang (ORCID: https://orcid.org/0000-0003-1620-0376)
- Zhihui Zhu (ORCID: https://orcid.org/0000-0002-3712-7238)
- Huajian Gu
- Ruisi Ma
- Shirui Huang
- Jun Du
Publication Details
- Journal
- Journal of Clinical and Translational Hepatology
- Published
- 2026-03-24
- DOI
- https://doi.org/10.14218/jcth.2025.00561
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00