Comparative evaluation of multimodal large language models for diagnostic accuracy in pediatric electrocardiography: a prospective comparative diagnostic accuracy study

• This is the[FCA1] first head-to-head comparative diagnostic accuracy study of multimodal LLMs in pediatric ECG evaluation, using likelihood ratios as primary outcome measures. • All three LLMs showed limited rule-in utility (+LR near 1.0); Gemini achieved potentially meaningful rule-out performance for emergency arrhythmias (-LR = 0.07), but with wide confidence intervals reflecting the small emergency subgroup (n = 22). • Gemini's 100% sensitivity in the emergency subgroup reflects overcalling (specificity 30.2%) consistent with a triage/screening behavior rather than diagnostic precision.

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Publication Details

Journal
European Journal of Pediatrics
Published
2026-03-24
DOI
https://doi.org/10.1007/s00431-026-06874-x
Primary Topic
ECG Monitoring and Analysis
Type
article
Field-Weighted Citation Impact
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article

Comparative evaluation of multimodal large language models for diagnostic accuracy in pediatric electrocardiography: a prospective comparative diagnostic accuracy study

European Journal of Pediatrics
ECG Monitoring and Analysis
article

Comparative evaluation of multimodal large language models for diagnostic accuracy in pediatric electrocardiography: a prospective comparative diagnostic accuracy study

article en

Abstract

• This is the[FCA1] first head-to-head comparative diagnostic accuracy study of multimodal LLMs in pediatric ECG evaluation, using likelihood ratios as primary outcome measures. • All three LLMs showed limited rule-in utility (+LR near 1.0); Gemini achieved potentially meaningful rule-out performance for emergency arrhythmias (-LR = 0.07), but with wide confidence intervals reflecting the small emergency subgroup (n = 22). • Gemini's 100% sensitivity in the emergency subgroup reflects overcalling (specificity 30.2%) consistent with a triage/screening behavior rather than diagnostic precision.

European Journal of PediatricsVol. 185(4)
Necmettin Erbakan University (TR)
Openalex Percentile: Top 20%
ECG Monitoring and Analysis
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