Heterogeneity and prognostic significance of mast cell subsets in the tumor microenvironment of prostate cancer

This study revealed functional heterogeneity of mast cell subsets in the TME of PC and their distinct roles in tumor progression. The identification of subset-specific marker genes provides novel molecular targets for clinical diagnosis, prognostic prediction, and personalized therapy in PC.

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Publication Details

Journal
Cancer Immunology Immunotherapy
Published
2026-03-24
DOI
https://doi.org/10.1007/s00262-026-04363-6
Primary Topic
Mast cells and histamine
Type
article
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article

Heterogeneity and prognostic significance of mast cell subsets in the tumor microenvironment of prostate cancer

Cancer Immunology Immunotherapy
Mast cells and histamine
article

Heterogeneity and prognostic significance of mast cell subsets in the tumor microenvironment of prostate cancer

article en

Abstract

This study revealed functional heterogeneity of mast cell subsets in the TME of PC and their distinct roles in tumor progression. The identification of subset-specific marker genes provides novel molecular targets for clinical diagnosis, prognostic prediction, and personalized therapy in PC.

Cancer Immunology ImmunotherapyVol. 75(4)
Harbin Medical University (CN), Beijing Anzhen Hospital (CN), Fourth Affiliated Hospital of Harbin Medical University (CN)
No poverty
Openalex Percentile: Top 10%
Mast cells and histamine
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