Advances in Mechanisms and Applications of Hydrogen‐Bond‐Mediated Asymmetric Gold Catalysis

Gold catalysis has emerged as crucial field in modern organic synthesis, experiencing rapid development over the past several decades. Gold(I) complexes, characterized as strong π‐acids with exceptional stability toward air and moisture, have offered new opportunities for chemical transformations. However, achieving efficient asymmetric catalysis remains a major challenge, as traditional chiral ligand design faces unique difficulties due to the linear coordination geometry of gold(I) complexes. In recent years, multiple strategies have been developed to enable asymmetric gold‐catalyzed transformations, yet the stereohindrance slows reaction rates and necessitates elevated catalyst loadings. Hydrogen bonding, as one of the most significant noncovalent interactions, has demonstrated increasing utility in both organocatalysis and metal catalysis. In gold catalysis, hydrogen bonds can participate in reaction control through multiple pathways, enabling more precise transmission of stereochemical information. From the perspective of reaction mechanisms, it analyzes the multiple pathways through which hydrogen bonds participate in reaction regulation to achieve the precise transmission of stereochemical information. This review provides a comprehensive and systematic overview of recent advances in hydrogen‐bond‐driven weak interactions for asymmetric control in gold catalysis.