Pharmacological evaluation of an <i>ex vivo</i> cervicovaginal HIV prevention model

We identified differences in DMET expression and ARV metabolism between ecto- and endocervical tissues, as well as correlations between DMET and IL-6. Ectocervical explants demonstrated consistent viral infectivity and dose-dependent inhibition. The model is useful in determining tenofovir diphosphate targets.

Publication Details

Journal: Journal of Antimicrobial Chemotherapy
Published: 2026-03-04
DOI: https://doi.org/10.1093/jac/dkag103
Primary Topic: Reproductive tract infections research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Pharmacological evaluation of an ex vivo cervicovaginal HIV prevention model

Mar 4, 2026

Journal of Antimicrobial Chemotherapy

Reproductive tract infections research

article

Pharmacological evaluation of an ex vivo cervicovaginal HIV prevention model

March 4, 2026article en

Abstract

Journal of Antimicrobial ChemotherapyVol. 81(4)

Good health and well-being

Openalex Percentile: Top 11%

Reproductive tract infections research

DOI Open Access PDF OpenAlex

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Pharmacological evaluation of an <i>ex vivo</i> cervicovaginal HIV prevention model · Journal of Antimicrobial Chemotherapy (2026) | TGRS Research Map | TGRS