How strong is a mitochondrial targeting signal?
In this issue, Yan et al. show that mitochondrial targeting signals (presequences) vary widely in import strength. Using the quantitative MitoLuc and PotLuc assays, they dissect multiple parameters of protein import and reveal how presequence features influence mitochondrial targeting efficiency and stress sensitivity.
Institutions
- University of Freiburg (DE)
- Heidelberg University (DE)
- DKFZ-ZMBH Alliance (DE)
- Heidelberg University (US)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2026-03-24
- DOI
- https://doi.org/10.1083/jcb.202603036
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00