THBS4 Regulates Pulmonary Hypertension via TGF-β/SMAD2 Signaling

Our findings identify THBS4 as a central regulator in a self-reinforcing THBS4-TGF-β/SMAD2 signaling axis driving pulmonary vascular remodeling. Targeting THBS4 represents a promising therapeutic strategy to mitigate pathological vascular remodeling in pulmonary hypertension.

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Publication Details

Journal
Hypertension
Published
2026-03-24
DOI
https://doi.org/10.1161/hypertensionaha.125.25968
Primary Topic
Pulmonary Hypertension Research and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

THBS4 Regulates Pulmonary Hypertension via TGF-β/SMAD2 Signaling

Hypertension
Pulmonary Hypertension Research and Treatments
article

THBS4 Regulates Pulmonary Hypertension via TGF-β/SMAD2 Signaling

article en

Abstract

Our findings identify THBS4 as a central regulator in a self-reinforcing THBS4-TGF-β/SMAD2 signaling axis driving pulmonary vascular remodeling. Targeting THBS4 represents a promising therapeutic strategy to mitigate pathological vascular remodeling in pulmonary hypertension.

Hypertension
Shenzhen University (CN), First People's Hospital of Yunnan Province (CN)
Good health and well-being
Openalex Percentile: Top 11%
Pulmonary Hypertension Research and Treatments
DOIOpen Access PDFOpenAlex
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THBS4 Regulates Pulmonary Hypertension via TGF-β/SMAD2 Signaling · Hypertension (2026) | TGRS Research Map | TGRS