Ancestry-specific genetics of amino acids and microbiota-related metabolites reveal causal effects on cardiometabolic disease in Chinese populations

These findings offer crucial insights into the ancestry-specific genetic determinants of metabolic traits, and shed new light on their causal roles in the etiology of cardiometabolic diseases in East Asian populations.

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Publication Details

Journal
Cardiovascular Diabetology
Published
2026-03-24
DOI
https://doi.org/10.1186/s12933-026-03122-2
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00
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article

Ancestry-specific genetics of amino acids and microbiota-related metabolites reveal causal effects on cardiometabolic disease in Chinese populations

Cardiovascular Diabetology
Genetic Associations and Epidemiology
article

Ancestry-specific genetics of amino acids and microbiota-related metabolites reveal causal effects on cardiometabolic disease in Chinese populations

article en

Abstract

These findings offer crucial insights into the ancestry-specific genetic determinants of metabolic traits, and shed new light on their causal roles in the etiology of cardiometabolic diseases in East Asian populations.

Cardiovascular Diabetology
University of Maryland, Baltimore (US), Fujian Medical University (CN), The University of Texas MD Anderson Cancer Center (US), Nanchang University (CN), Shandong University (CN), Harbin Medical University (CN), Sun Yat-sen University (CN), Guangxi Medical University (CN), Jilin University (CN), Anhui Medical University (CN), Wenzhou Medical University (CN), XinHua Hospital (CN), Ruijin Hospital (CN), First Affiliated Hospital of Wenzhou Medical University (CN), Affiliated Hospital of Southwest Medical University (CN), Jiading District Central Hospital (CN), Sun Yat-sen Memorial Hospital (CN), Dalian Municipal Central Hospital (CN), Jiangxi Provincial People's Hospital (CN), Shandong Provincial Hospital (CN), First Hospital of Jilin University (CN), First Affiliated Hospital of GuangXi Medical University (CN), Wuhan Union Hospital (CN), The Affiliated Yongchuan Hospital of Chongqing Medical University (CN), Second Affiliated Hospital of Harbin Medical University (CN), Zhejiang Center for Disease Control and Prevention (CN), First Affiliated Hospital of Anhui Medical University (CN), Fujian Provincial Hospital (CN), Karamay Central Hospital (CN), Jiangsu Province Hospital (CN), First Affiliated Hospital of Zhengzhou University (CN), Shanghai Clinical Research Center (CN), Tongji Hospital (CN), Chinese People's Liberation Army (CN), Qilu Hospital of Shandong University (CN), First Hospital of Lanzhou University (CN), Huazhong University of Science and Technology (CN), Lanzhou University (CN), Nanjing Medical University (CN), Chongqing Medical University (CN)
Good health and well-being
Openalex Percentile: Top 11%
Genetic Associations and Epidemiology
DOIOpen Access PDFOpenAlex
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