Progression of diabetic nephropathy and adverse renal outcomes: possible involvement of Toll-like receptor 4 expression

These findings indicate possible involvement of TLR4 expression in histological injury and poor renal prognosis in DN, especially before the development of extensive fibrosis. TLR4 and its endogenous ligands are potential novel therapeutic targets for DN.

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Publication Details

Journal
Clinical and Experimental Nephrology
Published
2026-03-24
DOI
https://doi.org/10.1007/s10157-026-02849-2
Primary Topic
Chronic Kidney Disease and Diabetes
Type
article
Field-Weighted Citation Impact
0.00
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article

Progression of diabetic nephropathy and adverse renal outcomes: possible involvement of Toll-like receptor 4 expression

Clinical and Experimental Nephrology
Chronic Kidney Disease and Diabetes
article

Progression of diabetic nephropathy and adverse renal outcomes: possible involvement of Toll-like receptor 4 expression

article en

Abstract

These findings indicate possible involvement of TLR4 expression in histological injury and poor renal prognosis in DN, especially before the development of extensive fibrosis. TLR4 and its endogenous ligands are potential novel therapeutic targets for DN.

Clinical and Experimental Nephrology
Akita University (JP), Nihonkai General Hospital (JP)
Good health and well-being
Openalex Percentile: Top 22%
Chronic Kidney Disease and Diabetes
DOIOpen Access PDFOpenAlex
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Progression of diabetic nephropathy and adverse renal outcomes: possible involvement of Toll-like receptor 4 expression · Clinical and Experimental Nephrology (2026) | TGRS Research Map | TGRS