“Memorare” a multidimensional intervention for people with major neurocognitive disorder: a series of six case studies

This feasibility pilot study explored the preliminary effects of a six-week multidimensional intervention, Memorare, in six male inpatients (mean age 72) with major neurocognitive disorder of various etiologies. The Memorare program combined cognitive stimulation and reminiscence therapy via the Musiquence platform with sensory stimulation using natural textures. Data collection included quantitative measures (MMSE, GDS-15, QOL-AD, NPI, BLAD) and qualitative observations (caregiver feedback, patient statements). Descriptive results indicated general cognitive function and mood declines, though improvements in neuropsychiatric symptoms and quality of life emerged in some cases. Limitations include the small, heterogeneous sample, absence of a control group, lack of randomization, and potential bias due to the same investigator conducting both interventions and assessments. Despite these constraints, findings suggest the feasibility and acceptability of person-centered, technology-assisted interventions for this population. These preliminary results support the relevance of personalized, non-pharmacological approaches in dementia care and underline the importance of conducting larger, controlled studies to validate their clinical efficacy and long-term benefits.