<i>Prevotella</i> ‐Derived Butyrate Inhibits <scp>CD8</scp> <sup>+</sup> T‐Cell Glycolysis via <scp>AKT</scp> / <scp>mTOR</scp> Signalling to Alleviate <scp>MASH</scp>

Prevotella mitigates MASH by downregulating the PI3K/AKT/mTOR-glycolysis axis in CD8<sup>+</sup> T cells via butyrate-dependent mechanisms, highlighting its potential as a microbial therapeutic candidate for MASH.

Publication Details

Journal
Liver International
Published
2026-03-24
DOI
https://doi.org/10.1111/liv.70613
Primary Topic
Peptidase Inhibition and Analysis
Type
article
Field-Weighted Citation Impact
0.00
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article

Prevotella ‐Derived Butyrate Inhibits CD8 + T‐Cell Glycolysis via AKT / mTOR Signalling to Alleviate MASH

Liver International
Peptidase Inhibition and Analysis
article

Prevotella ‐Derived Butyrate Inhibits CD8 + T‐Cell Glycolysis via AKT / mTOR Signalling to Alleviate MASH

article en

Abstract

Prevotella mitigates MASH by downregulating the PI3K/AKT/mTOR-glycolysis axis in CD8<sup>+</sup> T cells via butyrate-dependent mechanisms, highlighting its potential as a microbial therapeutic candidate for MASH.

Liver InternationalVol. 46(4)
Openalex Percentile: Top 10%
Peptidase Inhibition and Analysis
DOISourceOpenAlex
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<i>Prevotella</i> ‐Derived Butyrate Inhibits <scp>CD8</scp> <sup>+</sup> T‐Cell Glycolysis via <scp>AKT</scp> / <scp>mTOR</scp> Signalling to Alleviate <scp>MASH</scp> · Liver International (2026) | TGRS Research Map | TGRS