Gelsolin‐3: A Novel Myelin Autoantigen in Demyelinating Guillain‐Barré Syndrome

Anti-gelsolin-3 IgG1 represents a novel biomarker linking AIDP and BFP. Our results provide the first evidence that AIDP can be formally classified as a nodo-paranodopathy. This IgG1-mediated, complement-dependent nodal injury establishes a unifying paradigm across GBS: nodal complement activation represents a shared mechanism underlying conduction block despite targeting distinct domains-the axolemma in AMAN and myelin components at the axon-myelin interface in AIDP. ANN NEUROL 2026.