Clinical significance of miR-28-5p in ischemic stroke and its neuroprotective effect after ischemia-reperfusion injury

MiR-28-5p served as a diagnostic biomarker and independent prognostic factor in IS. Its neuroprotection involved suppressing WNK3-mediated microglial M1 polarization, oxidative stress, and inflammation, highlighting its potential as a therapeutic target for IS.

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Publication Details

Journal
Gerontology
Published
2026-03-24
DOI
https://doi.org/10.1159/000551361
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

Clinical significance of miR-28-5p in ischemic stroke and its neuroprotective effect after ischemia-reperfusion injury

Shuo Sun, Zhu Li, Yuhao Zhang, Hongfei Yang et al.
Gerontology
Neuroinflammation and Neurodegeneration Mechanisms
article

Clinical significance of miR-28-5p in ischemic stroke and its neuroprotective effect after ischemia-reperfusion injury

Shuo Sun, Zhu Li, Yuhao Zhang, Hongfei Yang, Jianchang Mu
article en

Abstract

MiR-28-5p served as a diagnostic biomarker and independent prognostic factor in IS. Its neuroprotection involved suppressing WNK3-mediated microglial M1 polarization, oxidative stress, and inflammation, highlighting its potential as a therapeutic target for IS.

Gerontology
Good health and well-being
Openalex Percentile: Top 28%
Neuroinflammation and Neurodegeneration Mechanisms
DOISourceOpenAlex
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