Sex Chromosome Turnover and Structural Genome Divergence Shapes Meiotic Outcomes in Hybridising <i>Cobitis</i>

Our results demonstrate that individual orthologous chromosomes differ markedly in their ability to form bivalents during meiosis in hybrids, indicating that hybrid meiotic behaviour is shaped by chromosome-specific incompatibilities rather than uniform genome-wide failure. We also found that even closely related parental species possess distinct, non-homologous sex chromosomes, highlighting rapid turnover of sex determination systems in hybridising lineages. Together, these findings provide a high-resolution genomic and cytogenetic framework to explore how the architecture of inherited parental genomes influences sex-specific reproductive outcomes in hybrids-ranging from male sterility to the establishment of fertile, clonally reproducing female lineages-and how such asymmetries may contribute to the emergence of asexuality in vertebrates.

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Publication Details

Journal
GigaScience
Published
2026-03-20
DOI
https://doi.org/10.1093/gigascience/giag031
Primary Topic
Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Type
article
Field-Weighted Citation Impact
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article

Sex Chromosome Turnover and Structural Genome Divergence Shapes Meiotic Outcomes in Hybridising Cobitis

GigaScience
Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
article

Sex Chromosome Turnover and Structural Genome Divergence Shapes Meiotic Outcomes in Hybridising Cobitis

article en

Abstract

Our results demonstrate that individual orthologous chromosomes differ markedly in their ability to form bivalents during meiosis in hybrids, indicating that hybrid meiotic behaviour is shaped by chromosome-specific incompatibilities rather than uniform genome-wide failure. We also found that even closely related parental species possess distinct, non-homologous sex chromosomes, highlighting rapid turnover of sex determination systems in hybridising lineages. Together, these findings provide a high-resolution genomic and cytogenetic framework to explore how the architecture of inherited parental genomes influences sex-specific reproductive outcomes in hybrids-ranging from male sterility to the establishment of fertile, clonally reproducing female lineages-and how such asymmetries may contribute to the emergence of asexuality in vertebrates.

GigaScience
Universitat Autònoma de Barcelona (ES), American Museum of Natural History (US), University of Ostrava (CZ), Universität Innsbruck (AT), Charles University (CZ), University of South Bohemia in České Budějovice (CZ), Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR), Institute for Biodiversity (DE), Zoological Research Museum Alexander Koenig (DE), Czech Academy of Sciences, Institute of Animal Physiology and Genetics (CZ), Leibniz Institute of Freshwater Ecology and Inland Fisheries (DE), German Environment Agency (DE), Military University Hospital Prague (CZ), Centre of the Region Haná for Biotechnical and Agricultural Research (CZ), Institute of Molecular Genetics (RU), Czech Academy of Sciences, Institute of Molecular Genetics (CZ), Laboratoire de Physiologie et Génomique des Poissons (FR), South Bohemia research center of aquaculture and biodiversity of hydrocenoses (CZ), Czech Academy of Sciences, Institute of Experimental Botany (CZ)
Openalex Percentile: Top 11%
Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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