Baseline resistance mutations and virological response to dolutegravir in treatment-naïve patients: a multicentre NGS study

Our findings indicate that pre-existing IN and RT DRM, including low-abundance and secondary/polymorphic variants, did not compromise the virological efficacy of dolutegravir-based triple therapy in ART-naïve individuals, supporting the high resistance barrier of dolutegravir and the lack of need for baseline resistance testing.

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Publication Details

Journal
Journal of Antimicrobial Chemotherapy
Published
2026-03-04
DOI
https://doi.org/10.1093/jac/dkag080
Primary Topic
HIV/AIDS drug development and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Baseline resistance mutations and virological response to dolutegravir in treatment-naïve patients: a multicentre NGS study

Journal of Antimicrobial Chemotherapy
HIV/AIDS drug development and treatment
article

Baseline resistance mutations and virological response to dolutegravir in treatment-naïve patients: a multicentre NGS study

article en

Abstract

Our findings indicate that pre-existing IN and RT DRM, including low-abundance and secondary/polymorphic variants, did not compromise the virological efficacy of dolutegravir-based triple therapy in ART-naïve individuals, supporting the high resistance barrier of dolutegravir and the lack of need for baseline resistance testing.

Journal of Antimicrobial ChemotherapyVol. 81(4)
Hospital Universitario de Canarias (ES), Instituto de Salud Carlos III (ES), Vall d'Hebron Institut de Recerca (ES), Centro de Investigación Biomédica en Red (ES), Hospital Clínic de Barcelona (ES), Vall d'Hebron Hospital Universitari (ES), Hospital General Universitario De Valencia (ES), Hospital Universitario de Valme (ES), Hospital Universitari Germans Trias i Pujol (ES), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
Openalex Percentile: Top 13%
HIV/AIDS drug development and treatment
DOISourceOpenAlex
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