Ocular Surface Microbiota-Derived Lipoteichoic Acid Promotes Dry Eye Disease by Inducing Corneal Inflammation
Our findings establish a mechanistic link between OSM-derived LTA and DED. LTA promotes ocular surface inflammation and dysfunction through TLR2 and PAFR signaling, suggesting that targeting microbial products or their receptors, such as PAFR, may offer a novel therapeutic strategy for DED.
Authors
- Li Zhong (ORCID: https://orcid.org/0000-0001-9828-3915)
- Lipu Cui
- Qingyu An (ORCID: https://orcid.org/0000-0001-5576-8605)
- Xinran Qin
- Lina Lu
- Haidong Zou
- Senlin Lin
- Yi Xu
Institutions
- Shanghai Eye Disease Prevention & Treatment Center (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-03-24
- DOI
- https://doi.org/10.1167/iovs.67.3.50
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00