The effect of medical therapies for subthreshold abdominal aortic aneurysm growth and mortality: a network meta-analysis of randomized controlled trials
Current evidence highlights ongoing uncertainty regarding the efficacy of medical therapies in reducing subthreshold AAA growth rates, rates of referral for surgical repair, or overall mortality. The absence of statistically significant benefit may reflect underpowered datasets rather than definitive treatment inefficacy. Future large-scale, appropriately powered randomized controlled trials evaluating emerging medical treatments are required to accurately assess their clinical potential.
Authors
- P. Lu (ORCID: https://orcid.org/0000-0003-0999-4462)
- Konrad Joseph (ORCID: https://orcid.org/0009-0008-4599-8747)
- Warren M. Rozen (ORCID: https://orcid.org/0000-0002-4092-182X)
- Ishith Seth (ORCID: https://orcid.org/0000-0001-5444-8925)
- Ramon L. Varcoe (ORCID: https://orcid.org/0000-0001-5611-6991)
- Casey Hiu Ching Fung
Institutions
- Frankston Hospital (AU)
- Prince of Wales Hospital (AU)
- Prince of Wales Hospital (CN)
- Peninsula Health (AU)
- Alfred Health (AU)
- Austin Health (AU)
Publication Details
- Journal
- Interdisciplinary CardioVascular and Thoracic Surgery
- Published
- 2026-03-21
- DOI
- https://doi.org/10.1093/icvts/ivag088
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00