The Role of Macrophages in Atopic Dermatitis

Atopic dermatitis (AD) is an allergic disease characterized by chronic inflammation and immune dysregulation, with pathogenesis involving a complex network of immune responses. Macrophages, as central components of the immune system, play diverse roles in AD: acting as promoters of inflammatory responses and potential facilitators of repair. This article reviews the functions of macrophages in AD, their molecular mechanisms, and interactions with other immune cells and explores future research directions and therapeutic strategies from the macrophage perspective.