Application of CRISPR/Cas13a system on the rapid detection of Salmonella spp.
We demonstrated that the CRISPR/Cas13a-SE system showed excellent detection performance for infectious diarrhea caused by Salmonella spp. The combined use of CRISPR/Cas13a-SE with the blood culture method enhances the rapid diagnosis of invasive salmonellosis, which is crucial for early target-based therapy. Additionally, screening of asymptomatic Salmonella carrier will be benefit for disease prevention and control.
Authors
- Ling Jiang (ORCID: https://orcid.org/0000-0003-2989-6309)
- Changhan Ai
- Zhenyi Huang
- Yongxin Huang
- Yingying Deng
- Weiqing Tan
- Wenli Liang
- Mingyao Huang
Institutions
- Nanyang Technological University (SG)
- Zhujiang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1371/journal.pntd.0014150
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00