Demographic determinants of REMS-derived BMD and fragility score

REMS-BMD and fragility scores are strongly influenced by demographic inputs, particularly age and weight. The REMS output therefore reflects an assessment of BMD and fracture risk strongly based on demographic parameters, rather than an ultrasound-based direct skeletal measurement. The results indicate the need for caution in individual patient assessment (particularly outliers), its application with FRAX calculations, and its use for longitudinal monitoring.