Cytomegalovirus Drives the Development of Cytotoxic CD4 <sup>+</sup> T Cells in Patients With Multiple Sclerosis
CMV was implicated as a dominant driver of development of highly cytotoxic CD4<sup>+</sup> T cells, as these cells were markedly enriched in CMV-seropositive individuals. This comprehensive phenotypic atlas of CD4 CTL advances our understanding of their development and highlights potential targets for diagnosing, treating, and preventing MS progression.
Authors
- Paulien Baeten (ORCID: https://orcid.org/0000-0002-6107-2177)
- Veronica Popescu (ORCID: https://orcid.org/0000-0002-7156-5442)
- Cindy Hoeks (ORCID: https://orcid.org/0000-0002-6249-9404)
- Niels Hellings (ORCID: https://orcid.org/0000-0003-2308-406X)
- Veerle Somers (ORCID: https://orcid.org/0000-0002-4950-8724)
- Doryssa Hermans (ORCID: https://orcid.org/0000-0003-2395-3376)
- Piet Stinissen (ORCID: https://orcid.org/0000-0002-4830-4084)
- Bram Boeckx (ORCID: https://orcid.org/0000-0002-0296-6680)
- Bieke Broux (ORCID: https://orcid.org/0000-0001-8509-2415)
- D. Lambrechts
- Joanna Randall
- Bart Van Wijmeersch
Institutions
- VIB-KU Leuven Center for Cancer Biology (BE)
- Centre For Human Genetics (IN)
- Center for Human Genetics (US)
- Hasselt University (BE)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1212/nxi.0000000000200561
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00