Disordered Bile Acid Metabolism in Alcohol‐Related Hepatitis

Serum conjugated primary BAs accumulate in AH. Elevated HGF may detrimentally affect the hepatoprotective adaptive reduction in NTCP/increase in BSEP seen in cholestasis, contributing to the AH BA profile.

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Publication Details

Journal
Alimentary Pharmacology & Therapeutics
Published
2026-03-23
DOI
https://doi.org/10.1111/apt.70616
Primary Topic
Alcohol Consumption and Health Effects
Type
article
Field-Weighted Citation Impact
0.00
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article

Disordered Bile Acid Metabolism in Alcohol‐Related Hepatitis

Alastair M. Kilpatrick, Mark R. Thursz, Elaine Holmes, Steven Masson et al.
Alimentary Pharmacology & Therapeutics
Alcohol Consumption and Health Effects
article

Disordered Bile Acid Metabolism in Alcohol‐Related Hepatitis

Alastair M. Kilpatrick, Mark R. Thursz, Elaine Holmes, Steven Masson, S Ryder, Nikhil Vergis, Luke D. Tyson, Daniel Rodrigo‐Torres, João Pedro Nunes, Vruti Patel, Katie Chappell, Prof Ewan Forrest, S. A. Forbes, B Mullish, Michael Allison, Paul Richardson, Andrew Austin, Laura Martinez‐Gili, Stephen Atkinson, Mark J. W. McPhail, Alexandros Pechlivanis, Tong Liu, Mark Wright
article en

Abstract

Serum conjugated primary BAs accumulate in AH. Elevated HGF may detrimentally affect the hepatoprotective adaptive reduction in NTCP/increase in BSEP seen in cholestasis, contributing to the AH BA profile.

Alimentary Pharmacology & Therapeutics
Nottingham University Hospitals NHS Trust (GB), University of Nottingham (GB), University of Liverpool (GB), Imperial College Healthcare NHS Trust (GB), King's College - North Carolina (US), Royal Derby Hospital (GB), Glasgow Royal Infirmary (GB), Royal Liverpool University Hospital (GB), University Hospital Southampton NHS Foundation Trust (GB), Foundation for Liver Research (GB), MRC Centre for Regenerative Medicine (GB), St Mary's Hospital (GB), NIHR Newcastle Biomedical Research Centre (GB), Queen's Medical Centre (GB), Nottingham Biomedical Research Centre (GB), King's College Hospital (GB), Addenbrooke's Hospital (GB), Meso Scale Discovery (United States) (US), Imperial College London (GB), University of Glasgow (GB)
Zero hunger
Openalex Percentile: Top 12%
Alcohol Consumption and Health Effects
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