LY294002 and LiCl Mitigate Neonatal ExPEC Meningitis Through Akt/GSK3β Signaling Modulation
LY294002 and LiCl reduced neuroinflammation and preserved the blood-brain barrier (BBB) integrity in the neonatal ExPEC meningitis model, likely via modulation of the Akt/GSK3β pathway. These results underscore the potential of this pathway as a therapeutic target and provide a basis for further preclinical investigation.
Authors
- Sihan Sheng
- Ruiqi Xiao (ORCID: https://orcid.org/0000-0002-0445-7791)
- Peipei Zhang (ORCID: https://orcid.org/0000-0002-1878-3803)
- Pan Huang
- Yue Du
- Peicen Zou
- Yajuan Wang
- Ying Chen
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Capital Institute of Pediatrics (CN)
Publication Details
- Journal
- Mediators of Inflammation
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1155/mi/5086440
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00