MYELOstudy: lymph node stage of aggressiveness in medullary thyroid cancer-a retrospective multi-center study analysis.

Medullary thyroid carcinoma (MTC) is a rare, but biologically aggressive cancer that accounts for 1-2% of all thyroid malignancies. Its aggressiveness has been linked to distinct clinicopathological features. Novel pathological predictors of aggressiveness have also been described in the literature. However, these remain contentious, to date. To assess the prognosticators of aggressiveness for MTC and establish potentially novel ones. The primary endpoint was to establish predictors for central and/or lateral cervical nodal metastatic disease. Whereas secondary endpoints include defining biochemical and histopathologic markers of aggressiveness. A multi-center retrospective analysis of prognosticators of aggressiveness in MTC. 785 patients with MTC were enrolled. The mean age was 56 years with a female to male ratio of 1: 1.7. Regression analysis demonstrated that aggressive prognosticator predictive of nodal metastasis included: age, pre- and post-operative Calcitonin and CEA levels, tumor size, multifocality, capsular and lymphovascular invasion, the presence of extrathyroidal extension, Ki-67, and RET positivity, desmoplasia, and inflammatory scores. This study provides an expanded spectrum of prognosticators of tumor aggressiveness. Furthermore, it also highlights the potential meaningful therapeutic implications of preoperative inflammatory scores, tumor desmoplastic reaction, and metastatic nodal ratio.

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Open Access CRIS of the University of Bern
Published
2026-01-01
DOI
https://doi.org/10.48620/96251
Primary Topic
Thyroid Cancer Diagnosis and Treatment
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article
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article

MYELOstudy: lymph node stage of aggressiveness in medullary thyroid cancer-a retrospective multi-center study analysis.

Theodossis S. Papavramidis, Rangsima Aroonroch, Cédric Nesti, Reto Martin Kaderli et al.
Open Access CRIS of the University of Bern
Thyroid Cancer Diagnosis and Treatment
article

MYELOstudy: lymph node stage of aggressiveness in medullary thyroid cancer-a retrospective multi-center study analysis.

Theodossis S. Papavramidis, Rangsima Aroonroch, Cédric Nesti, Reto Martin Kaderli, Michele Minuto, Robert Grützmann, Mateo Cukman, Tom Chi-Man Chow, Olga Senashova, Burlacu Maria-Cristina, Andro Tarle, Aliende Lengler Abentroth, Muthuswamy Dhiwakar, Maximilian Brunner, Ioannis Koutelidakis, Rumen Pandev, Maria Boudina, Fábio Muradás Girardi, Luigi Oragano, Manuela Mastronardi, Stavros Karakozis, Monica Leutner, Maisie L. Shindo, Maciej Śledziński, Chiara Dobrinja, Luca Castellani, Constantinos Nastos, Luiz Alberto Hauth, Alexandra Chrisoulidou, Andrzej Rafal Hellmann, Nathalie Massé, Evangelia Bellou, Giuseppe Placentino, Michael de Cillia, Viyey Kishore Doulatram Gamgaram, Serkan Teksöz, Carmela De Crea, Lampros Karakozis, Paula La Rubia, Óscar Vidal, Volkan Genç, Emanuela Varaldo, Eleonora Morelli, Rajeshwari K Muthusamy, Michael Katsamakas, Andrés Chala, Selen Soylu Yalıman, Francesco Pennestrì, Akif Enes Arikan, Frederic Triponez, Marti Manyalich, İlgiz Tüzken, Andro Košec, MUSTAFA ANIL TURHAN, Roxana Da Milano, Maria Banus, Onur Dulgeroglu, Furnica Raluca-Maria, Lokesh Kathirvel, Demarchi Marco, Jean-Christophe Leclère, Ramacciotti Constanza, Hadj Omar El Malki, Marta Iturregui Guevara, Marco Raffaelli, Van Trung Hoang, Giacomo Di Filippo, Moysis Moysidis, Pietro Giorgio Calò, Federico Cappellacci, Aida Orois, Chutintorn Sriphrapradang, Ramakanth Bhargav Panchangam, Nikolaos Voloudakis, Manuela Albertelli, Sohail Bakkar, James Y Lim, Ioannis Pliakos, Man Wai Katherine Lai, Loredana de Pasquale, Cihan Uras, Giovanni Lazzari, Sergii Cherenko, Liuchiia Shchekaturova, Jiannis Hajiioannou, Antoine Buemi, Angeliki Chorti, Fabio Medas, Gian Luigi Canu, Shirley Yuk-Wah Liu, Lovenish Bains
article en

Abstract

Medullary thyroid carcinoma (MTC) is a rare, but biologically aggressive cancer that accounts for 1-2% of all thyroid malignancies. Its aggressiveness has been linked to distinct clinicopathological features. Novel pathological predictors of aggressiveness have also been described in the literature. However, these remain contentious, to date. To assess the prognosticators of aggressiveness for MTC and establish potentially novel ones. The primary endpoint was to establish predictors for central and/or lateral cervical nodal metastatic disease. Whereas secondary endpoints include defining biochemical and histopathologic markers of aggressiveness. A multi-center retrospective analysis of prognosticators of aggressiveness in MTC. 785 patients with MTC were enrolled. The mean age was 56 years with a female to male ratio of 1: 1.7. Regression analysis demonstrated that aggressive prognosticator predictive of nodal metastasis included: age, pre- and post-operative Calcitonin and CEA levels, tumor size, multifocality, capsular and lymphovascular invasion, the presence of extrathyroidal extension, Ki-67, and RET positivity, desmoplasia, and inflammatory scores. This study provides an expanded spectrum of prognosticators of tumor aggressiveness. Furthermore, it also highlights the potential meaningful therapeutic implications of preoperative inflammatory scores, tumor desmoplastic reaction, and metastatic nodal ratio.

Open Access CRIS of the University of Bern
Tracer Technologies (United States) (US)
Good health and well-being
Openalex Percentile: Top 14%
Thyroid Cancer Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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