The Genetics of TDP-43 Type C Neurodegeneration
This study provides replicated evidence for the association between common variants in <i>ANXA11</i> with TDP-C. Knowing rs1079242-A affects ANXA11 level in CSF, future studies may aim to investigate ANXA11 level as potential CSF biomarker for TDP-C. Moreover, <i>FIG4 and ANXA11</i> have been implicated in the inositol pathway. Our results provide novel insights into the genetic risk of TDP-C and offer new clues about its underpinning mechanisms.
Authors
- Anna Bonfitto (ORCID: https://orcid.org/0009-0001-5796-5167)
- Ivan N. Ayala (ORCID: https://orcid.org/0000-0002-2997-3848)
- Malik Nassan (ORCID: https://orcid.org/0000-0002-6182-4340)
- Tamar Gefen (ORCID: https://orcid.org/0000-0002-2380-3100)
- Matthew J. Huentelman (ORCID: https://orcid.org/0000-0001-7390-9918)
- Serena Song
- Jennifer L. Sloan (ORCID: https://orcid.org/0000-0003-4520-0949)
- Ignazio Stefano Piras (ORCID: https://orcid.org/0000-0003-4024-3368)
- Marcus Naymik
- Changiz Geula
- Elena Barbieri
- Bobbi Stark
- M.-Marsel Mesulam
Institutions
- Northwestern University (US)
- Translational Genomics Research Institute (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
Publication Details
- Journal
- Neurology Genetics
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1212/nxg.0000000000200369
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00