Causal effects of drug exposure on gastric cancer risk: a Mendelian randomization study involving 23 commonly used medications in the European population

This study revealed negative genetically proxied associations related to drug targets of anti-migraine formulations, drugs acting on the renin-angiotensin system, and adrenergic drugs/inhalants with gastric cancer risk. These hypothesis-generating findings may help inform future mechanistic and clinical investigations.

Authors

Institutions

Publication Details

Journal
Discover Oncology
Published
2026-03-23
DOI
https://doi.org/10.1007/s12672-026-04672-3
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Causal effects of drug exposure on gastric cancer risk: a Mendelian randomization study involving 23 commonly used medications in the European population

Jindan Xia, Ganlu Zhang, Wangxia Lv, Dashan Yin et al.
Discover Oncology
Genetic Associations and Epidemiology
article

Causal effects of drug exposure on gastric cancer risk: a Mendelian randomization study involving 23 commonly used medications in the European population

Jindan Xia, Ganlu Zhang, Wangxia Lv, Dashan Yin, Jin Qian, Yi Zhou
article en

Abstract

This study revealed negative genetically proxied associations related to drug targets of anti-migraine formulations, drugs acting on the renin-angiotensin system, and adrenergic drugs/inhalants with gastric cancer risk. These hypothesis-generating findings may help inform future mechanistic and clinical investigations.

Discover Oncology
Zhejiang Chinese Medical University (CN), Chinese Academy of Sciences (CN), First People's Hospital of Yuhang District (CN), Zhejiang Cancer Hospital (CN), Zhejiang Hospital (CN), Zhejiang University (CN)
Good health and well-being
Openalex Percentile: Top 11%
Genetic Associations and Epidemiology
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Causal effects of drug exposure on gastric cancer risk: a Mendelian randomization study involving 23 commonly used medications in the European population — Jindan Xia, Ganlu Zhang, et al. · Discover Oncology (2026) | TGRS Research Map | TGRS